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KMID : 0370219880320060428
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Yakhak Hoeji
1988 Volume.32 No. 6 p.428 ~ p.434
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Effects fo calcium and calcium antagonist nifedipine on the glycogenolysis induced by the stimulation of alpha-and beta-adrenergic receptors in rat hepatocytes
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Abstract
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The effects of calcium and calcium antagonist, nifedipine on the adrenergic receptor-stimulated glycogenolysis were investigated in isolated rat hepatocytes. The hepatic glycogenolysis induced by alpha-adrenergic receptor stimulation depended on calcium ions, and betaadrenergic activation was unrelated to calcium ions. Nifedipine decreased the alpha-adrenergic agonist-induced glucose release significantly and the decrease was depended on calcium ions. The glucose release induced by beta-adrenergic agonist was not inhibited by nifedipine.
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